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The approval is supported by three Phase III trials, including INTEGUMENT-1 and INTEGUMENT-2
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If the weight is coming off too quickly, you may need to downregulate a dose or perhaps switch to a medicine that’s less potent.” Siegel points out that the lower 4 mg retatrutide dose yielded a 19 percent body weight reduction, with a significantly lower rate of discontinuation, suggesting this may be a more tolerable option for many